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The methods of the PHS have been described in detail elsewhere.9-11 In brief, 22 071 US male physicians aged 40 to 84 years at entry in 1982 92.1% white ; with no history of MI, stroke, transient ischemic attack, or cancer except nonmelanoma skin cancer ; were assigned to aspirin or beta carotene in a randomized, double-blind, placebo-controlled, 2 factorial trial. At baseline, the physicians completed questionnaires that elicited information about height and weight, use of cigarettes and alcohol, and frequency of physical activity, as well as information about history of hypertension, high cholesterol levels, diabetes mellitus, and parental history of MI before age 60 years. FOLLOW-UP Every 6 months for the first year and annually thereafter, follow-up questionnaires were mailed to the study participants to obtain information about the occurrence of new medical diagnoses. Medical records were obtained and reviewed by the Endpoints Committee to confirm the selfreported diagnosis of MI using World Health Organization criteria12 ; , angina, and coronary revascularization procedures coronary artery bypass graft or percutaneous coronary angioplasty ; . A validation study confirmed the selfreport for 97.8% of the cases of angina, as described elsewhere.9 In 11 years of follow-up, there were 1305 cases of angina, 550 cases of nonfatal MI, and 1089 coronary revascularization procedures. For our primary analyses, we used a combined end point of the first reported CHD event n 1446 ; . We also examined types of CHD events separately. Vital status was known for more than 99% of participants. ASSESSMENT OF HAIR LOSS On the 11-year follow-up questionnaire, participants were asked "Which of the following most closely approximates your hair pattern at age 45?" and were given 5 possible choices13 for their answers, as shown in the Figure . These 5 sketches were based on the Hamilton scale.

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And 5 growth factors ; . Statistical analysis was performed by t-test with significance accepted at p 0.05. Results: Leukocytes, macrophages, dendritic, endothelial cells and fibroblasts could not be detected in either autologous or in allogeneic transplants. Histological analysis revealed an increased proportion of terminal differentiated suprabasal cells in the allograft group compared to a higher proportion of proliferative basal cells in the autologous group. Both culture groups expressed large amounts of IL-1RA and IL-8 with no significant difference between the groups. IL-6 and GM-CSF were significantly increased in the burn group during the first 15 days of culture compared to controls p 0.05 ; . Conclusion: Epidermal basal cells from burns show increased proliferative activity with increased mediator release. by skin grafting is a life-saving procedure 5 WOUND COVERAGE WITH MICROBIAL NANOCELLULOSE IN TREATMENT OF DONOR SITE WOUNDS AND SKIN AUTOGRAFTS AFTER SEVERE BURNS Ludwik K. Branski1, Wojciech Czaja2, Marc G. Jeschke1, William B. Norbury1, Oscar E. Masters1, Yoshimitsu Nakano1, Daniel L. Taber1, R. Malcolm Brown2 and David N. Herndon11Shriners Hospital for Children and University of Texas Medical Branch, Galveston, Texas2University of Texas at Austin Introduction: In severely burned patients, early wound closure is essential and the choice of the correct dressing paramount. Microbial Nanocellulose NC ; , an inert material produced by Acetobacter xylinum, has emerged as a new coverage material that is very conformable, can hold a large amount of liquid, and retains a high mechanical strength, therefore making it an ideal wound dressing. Our aim was to compare NC and standard dressing material in a porcine burn wound model. Materials and Methods: Third degree burn wounds Treatment: n 10, control: n 8, ; were created using hot aluminum, excised 24h post injury and grafted with autologous skin transplant 4: 1 meshgraft, wound size: 50cm2 ; . Donor sites Treatment: n 10, Control: n 8 ; were created using an electric dermatome. Oil emulsion dressing Adaptic, Ethicon, Inc. ; was used as control. Dressing changes were performed and standardized digital photographs taken at 2, 5, 9 and 14 days post injury. Re-epitheliazation, graft adherence, rate of infections, hematoma, fibrin deposition and rate of hypergranulation were assessed at each time point using a macroscopic grading scale. Results: In grafted wounds covered with NC, infections and hematoma occurred significantly less than in the controls at day 5 and 9 p 0.05 ; . Graft adherence was significantly improved at day 9 p 0.003 ; . Donor site wounds treated with NC showed significantly less fibrin deposition, hematoma, hypergranulation, and increased re-epitheliazation at day 9 p 0.04 ; . 60% of the wounds in the NC-group vs. 20% in the control group were completely healed at this timepoint. Conclusion: In a large animal trial, Microbial Nanocellulose accelerates wound healing and proves to be a safe and efficacious wound coverage material for donor sites and grafted wounds. 6 BISMUTH SUBGALLATE BORNEAL SUILE ; VS NANOCRYSTALLINE SILVER IN THE HUMAN FOREARM BIOPSY MODEL FOR ACUTE WOUND HEALING Thomas E. Serena MD FACS1, 2, Laura K.S. Parnell3 , Michelle Kauffman PA-C JD1Gannon University1; Penn North Centers for Advanced Wound Care2; NewBridge Medical Research2; Precision Consulting3 Background: The human forearm biopsy model has been employed to evaluate established and novel agents in acute wounds. Bismuth Subgallate Borneol Suile ; is a new product with FDA permission for the treatment of partial thickness wounds. It was shown to be more effective than Bacitracin in an earlier forearm biopsy study. It has been suggested that its efficacy is due to its antiinflammatory properties; although, it also has significant antimicrobial activity. This study focuses on its comparison to a commonly used antimicrobial dressing, Acticoat 3TM Smith and Nephew ; . Actcoat is a silver-coated high-density polyethylene mesh. Methods: In a randomized, investigator-blinded study, 40 normal healthy volunteers underwent two 6mm full-thickness skin punch biopsies on the flexor surface of each forearm two wounds subject ; . Biopsies were randomly assigned to receive Suile or Acticoat 3. Wounds were examined, measured and photographed daily until healed. Adverse events were monitored. Time-to-complete closure was determined. Results: Direct quantitative and qualitative comparisons of wound healing were observed. There was a trend toward more rapid healing in the Suile group particularly when the time to closure was examined on an individual basis: comparing the healing times between a subject's two biopsies. The subjects reported more that the Suile dressing was more comfortable and demonstrated less skin discoloration. Conclusion: Suile has been shown to be an effective wound healing agent in the forearm biopsy model. Based on the results of this and earlier studies its effect in this model appears to be due largely to its anti-inflammatory properties as opposed to its antimicrobial activity. Finally, the human forearm biopsy model has several advantages: direct comparison within subjects, rapid study completion, good patient compliance, and experience with products prior to embarking on larger clinical trials in wounds. Acknowledgement: Unrestricted Grant from Hedonist Biochemical Technologies. Co. 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