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Incrocci, Erasmus MC-Daniel den Hoed Cancer Center, Department of Radiation Oncology, P.O. Box 5201, 3008 AE Rotterdam, Netherlands] - ACTA ONCOL. 2005 44 7 ; - summ in ENGL Incidence of erectile dysfunction ED ; after radiotherapy reported in the literature varies from 7 to 72% after external-beam radiotherapy to 5-51% after brachytherapy. Most of these studies are retrospective, the definition of ED is variable and sexual functioning is frequently assessed by asking only one question. Already in the 1980's it was suggested that post-radiation ED was attributable to vascular damage. The most reliable method to assess vasculogenic ED is the use of the Doppler ultrasound. More recently, many studies have assessed the relationship between radiation dose and volume of the penile bulb and post-radiation ED, though the outcome is controversial. The penile structures and the neurovascular bundles are best seen on magnetic resonance imaging MRI ; . Therefore the use of a computer tomography scan MRI image fusion can result in reducing the planning target volume and consequently the radiation dose to the penile bulb and bodies. If radiation induces vascular damage that causes ED, any means of reducing the dose to the pelvic vascular structures would likely decrease ED, therefore new radiation techniques such as the intensity modulated radiation therapy or the implant of fiducial markers can help decrease the margins and therefore ED. 2005 Taylor & Francis. 673. Living after radical prostatectomy for localized prostate cancer: A qualitative analysis of patient narratives - Hedestig O., Sandman P.-O., Tomic R. and Widmark A. [O. Hedestig, Department of Nursing, Umea University, S-901 85 Umea, Sweden] ACTA ONCOL. 2005 44 7 ; - summ in ENGL The purpose of this study was to illuminate the experience of living after radical prostatectomy RP ; for localized prostate cancer LPC ; . Ten men were interviewed after RP. The interview text was qualitatively analyzed using the content analysis. The men suffered from worry, anxiety, and distress, and longed for life as they had lived it before the diagnosis. Changes in bodily functions after RP include urine incontinence UI ; and or erectile dysfunction ED ; making the patient feel like a changed man with a lost sex life, with changes in his intimate relations with his wife, and with lowered self-esteem. Most men choose to cope on their own. Coping strategies in our study population included finding new areas of interest and a new focus in the present. In the present study, living after RP meant striving to gain control over, and become reconciled with, the new life situation as a changed man living with an altered self. 2005 Taylor & Francis. 674. Serum tartrate-resistant acid phosphatase 5b TRACP 5b ; as a marker of skeletal changes in prostate cancer - Salminen E., Ala-Houhala M., Korpela J. et al. [E. Salminen, Department of Oncology and Radiotherapy, Turku University Hospital, POB 52, Fin-20521 Turku, Finland] - ACTA ONCOL. 2005 44 7 ; summ in ENGL Skeletal metastases are a significant problem in prostate cancer PC ; . The patients are also exposed to treatment-related skeletal changes. This cross-sectional study evaluated a marker of bone resorption, TRACP 5b in relation to the standard analyte total alkaline phosphatase tALP ; as a marker of skeletal changes. Serum levels of TRACP 5b, tALP and PSA were measured in 130 prostate cancer patients. Comparison was made between patients with BM + , n and without BM-, n 105 ; skeletal metastases, and between those treated with n 64 ; or without n 66 ; androgen deprivation AD ; . Sensitivities and specificities were calculated for each marker and diagnostic accuracy was evaluated by ROC curve analysis. ROC curves indicated the superior accuracy of tALP, whereas TRACP 5b and PSA were comparable. With tALP the best combination of sensitivity 96% ; and specificity of 91% ; was reached at a cut-off point 224 U L, the corresponding values were for TRACP 5b sensitivity 76% ; , specificity 89% ; with a cut-off point 4.89 U L, and for PSA sensitivity 65% ; , specificity 81% ; at 23 ng L for skeletal metastases. Patients treated with AD showed with increasing duration an increase in TRACP 5b values. TRACP 5b was less specific than tALP as a marker of skeletal metastases. TRACP 5b may have a role in the diagnostics of skeletal changes Section 16 vol 143.2.

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